A New Paradigm for Radiation-Induced Toxicity Analysis: Space Based Normal Tissue Complication Probability Modeling

Treatment of radiation-induced normal tissue lesions

A Stochastic Model for the Normal Tissue Complication Probability (NTCP) in Radiation Treatment of Cancer

The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth death process to define an organ specific and patient specific NTCP. We emphasise an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework allows for a direct ...

Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer

BACKGROUND The risk of radio-induced gastrointestinal (GI) complications is affected by several factors other than the dose to the rectum such as patient characteristics, hormonal or antihypertensive therapy, and acute rectal toxicity. Purpose of this work is to study clinical and dosimetric parameters impacting on late GI toxicity after prostate external beam radiotherapy (RT) and to establish...

Comparing of different normal tissue complication probability models for plan evaluation of radical radiotherapy for esophageal cancer

Introduction: Chemoradiation is a well-established protocol for management of localized esophageal cancer. However, some early and late toxicities are associated with this therapy. Plan evaluation in term of normal tissue complication probability (NTCP) may help clinicians to tailor this therapy more individually. Given the variety of present radiobiological models, the choice...

Normal tissue complication probability modeling for cochlea constraints to avoid causing tinnitus after head-and-neck intensity-modulated radiation therapy

BACKGROUND Radiation-induced tinnitus is a side effect of radiotherapy in the inner ear for cancers of the head and neck. Effective dose constraints for protecting the cochlea are under-reported. The aim of this study is to determine the cochlea dose limitation to avoid causing tinnitus after head-and-neck cancer (HNC) intensity-modulated radiation therapy (IMRT). METHODS In total 211 patient...